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July 19, 2021

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Title: An in Vitro Study of the Effects of Cassia Podocarpa Fruit on the Intestinal Motility of Rats.
Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
Release Date : January 01, 2004
Genre: Life Sciences,Books,Science & Nature,
Pages : * pages
Size : 207 KB

Description

Summary Folkloric evidence and scientific reports indicate the use of C. podocarpa fruit as a purgative recipe. This study attempts to find the in vitro effects of its aqueous infusion (ACPF) and methanolic extract (MCPF) on the motility of the intestine of albino rats of Wistar strain and to compare their effect with those of C. acutifolia fruit (ACAF and MCAF). MCPF relaxed both the ileum and colon dose dependently. Its effect was blocked by tolazoline ([10.sup.-9] M) and propranolol ([10.sup.-9] M). ACPF had no effect on the ileum, but contracted the colon dose-dependently. Its effect was blocked by nifedipine (2.8 X [10.sup.-10] M) and drastically reduced by atropine (3.4 X [10.sup.-6] M). MCAF has the same effect as ACPF on both ileum and colon and its effect was similarly affected by atropine (3.4 X [10.sup.-6] M) and nifedipine (2.8 X [10.sup.-8] M). ACAF relaxed the ileum, its effect was blocked by tolazoline (5.1 X [10.sup.-7] M). MCAF was more potent than ACPF in contracting the colon, Hexamethonium (2.8 X [10.sup.-8] M), chlorpheniramine (3.8 X [10.sup.-8] M) and promethazine (3.2 X [10.sup.-10] M) potentiated the effect of ACPF on the colon. The results suggest that both ACAF and MCPF have anti-diarrhoeal effect. MCPF acts via both [alpha] and [beta] adrenergic receptor stimulation, while ACAF stimulates [alpha]-receptor. ACPF and MCAF engage both the cholinergic system and calcium channel activation in causing purgation in the colon. The potentiation of the effect of ACPF by some blockers could be due to allosteric enhancement of the receptors involved in its action.